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KMID : 0363320030240020220
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 2 p.220 ~ p.232
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Effects of HwangRyunHaeDok-Tang and Constituent Herbs on a Contracted Artery of Rabbit
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Kwon Oh-Yul
Nam Chang-Gyu
Kim Ho-Hyun
Jeong Chan-Gil
Sung Hyun-Jea
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Abstract
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Objective : The purpose of this study was to analyze the effects of HwangRyunHaeDok-Tang and combinations of constituent herbs on the arterial contraction.
Methods : In order to investigate the effects Scutellariae Radix. Coptidis Rhizoma, Phellodendri Cortex and Gardeniae Fructus, in which one of them, two of them, and all of them, were used to exam.
Results : The results were summarized as follows;
1. HwangRyunHaeDok-Tang significantly inhibited the contraction of artery induced by Norepinephrine(NE). However the atonic effect was slightly blunted when the vascular endothelial cell was removed. No significant change in the atonic effect of HwangRyunHaeDok-Tang was found when _L-NNA was used as a preliminary treatment. These results indicate that the vascular atonic effect by HwangRyunHaeDok-Tang is slightly dependent on the endothelial cell, and that the HwangRyunHaeDok-Tang works directly to the vascular smooth muscle in creating the vascular atonic effect.
2. The pretreatment of HwangRyunHaeDok-Tang extract significantly inhibited the contractile response to additive application of Ca{2+} in the strips which were contracted by NE in Ca{2+}-free solution.
3. HwangRyunHaeDok-Tang extract increased the contraction of arterial smooth muscle induced by KCl. Therefore, it can be concluded that HwangRyunHaeDok-Tang may block the NE-receptor or receptor-operated Ca{2+} channel.
4. It was determined that Scutellariae Radix, Coptidis Rhizoma and Phellodendri Cortex among the ingredients of HwangRyunHaeDok-Tang have a vascular atonic effect. In addition, those ingredients plays a role in strengthening the atonic effect by working with other herbal medicines. Gardeniae Fructus causes the blood vessel to contract. but it does not influence the atonic effects of other herbal medicines. However Gardeniae Fructus tends to inhibit the vascular atonic effect of Phellodendri Cortex.
Conclusion : Based on the above results, it can be said that HwangRyunHaeDok-Tang can be applied to cure hypertension considering those three herbs have significant effects of relaxation.
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KEYWORD
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HwangRyunHaeDok-Tang, Scutellariae Radix, Coptidis Rhizoma, Phellodendri Cortex, Gardeniae Fructus, hypertension
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